Is Amlodipine Safe in Pregnancy

Reason

Limited pregnancy data, but official sources do not think it is harmful. Provider review is advised.

Drug Information

Brand Name

Norvasc

Generic Name

amlodipine

Drug Class

calcium channel blocker (dihydropyridine antihypertensive)

FDA Category

N/A (PLLR narrative label)

Rx Status

prescription

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit.

Effects

Pregnancy

Can be used in pregnancy when needed. Your provider may keep it or switch to a better-studied medicine.

Mother

May help control blood pressure. Possible side effects include dizziness, swelling, and low blood pressure.

Baby

Limited data do not show an increased risk of birth defects. Monitor growth as directed by your provider.

Trimester Notes

1st Trimester

Limited early-pregnancy data do not show a higher birth-defect risk, but evidence is limited.

2nd Trimester

Can be continued if benefits outweigh risks and blood pressure is controlled.

3rd Trimester

Can be used if needed. Your provider may monitor blood pressure and fetal growth.

Risk-Benefit Note

For antihypertensives, the benefit of treating maternal hypertension may outweigh the limited medication risk. Do not stop amlodipine without your prescriber’s advice.

Conditions & Warnings

• Consult OB/GYN or prescriber
• Do not stop or switch without medical advice
• Blood pressure control during pregnancy
• Limited official data

Alternatives

• Nifedipine
• Labetalol
• Methyldopa

References

• NHS
  https://www.nhs.uk/medicines/amlodipine/pregnancy-breastfeeding-and-fertility-while-taking-amlodipine/
• FDA
  null
• ACOG
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