Amoxicillin

Status

caution Last reviewed: 2026-05-16 · Confidence: high

Reason

Pregnancy data are generally reassuring, but official labels say use only if clearly needed.

Drug Information

Brand Name
Amoxil
Generic Name
amoxicillin
Drug Class
penicillin antibiotic
FDA Category
B
Rx Status
prescription

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit.

Effects

Pregnancy
Official labeling says use only if clearly needed. Pregnancy can change amoxicillin clearance, so provider review matters.
Mother
May treat bacterial infections in pregnancy; drug levels can change during pregnancy, so dosing may need review.
Baby
No clear increase in major birth defects has been found in official labeling; limited data suggest possible oral cleft signal in early pregnancy is not confirmed.

Trimester Notes

1st Trimester
Official labeling allows use only if clearly needed. Limited observational data include a possible oral cleft signal with early exposure, but findings are inconsistent.
2nd Trimester
Generally considered acceptable when needed for bacterial infection, but provider should confirm dose and need.
3rd Trimester
Official sources note pregnancy can increase amoxicillin clearance later in pregnancy; provider may review dose and interval.

Conditions & Warnings

  • Consult OB/GYN or prescriber
  • Prescription drug: do not start, stop, or change dose without provider guidance
  • Pregnancy dosing may need adjustment by your provider

Alternatives

  • Penicillin V
  • Cephalexin
  • Discuss the best antibiotic with your OB/GYN or prescriber

References

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