Is Ampiclox Safe in Pregnancy

Status

caution Last reviewed: 2026-05-16 · Confidence: low

Reason

Limited official pregnancy data. Penicillins are generally used when needed, but provider review is advised.

Drug Information

Brand Name
Ampiclox
Generic Name
ampicillin + cloxacillin
Drug Class
penicillin antibiotic combination
FDA Category
unknown
Rx Status
prescription

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit.

Effects

Pregnancy
Use only when the benefit is expected to outweigh the risk. Treating infection matters in pregnancy.
Mother
May cause allergic reactions, stomach upset, diarrhea, or yeast infection.
Baby
May cross the placenta. Limited direct data for this exact combination.

Trimester Notes

1st Trimester
Limited data for the exact combination. Use only if your provider feels it is needed.
2nd Trimester
Limited data for the exact combination. Use only if your provider feels it is needed.
3rd Trimester
No trimester-specific official warning found for this exact product. Provider review is still needed.

Risk-Benefit Note

If you need an antibiotic in pregnancy, your prescriber will choose the safest option for the infection and your allergy history. Do not stop a prescribed antibiotic without medical advice.

Conditions & Warnings

  • Consult OB/GYN or prescriber
  • Prescription drug: do not start or stop without provider advice
  • Limited pregnancy data for the exact combination
  • If you have penicillin allergy, tell your provider

Alternatives

  • Amoxicillin or ampicillin only if your provider chooses them
  • Cephalexin or other pregnancy-appropriate antibiotic if prescribed by your clinician

References

  • ACOG
    https://www.acog.org/clinical/clinical-guidance/clinical-consensus/articles/2023/08/urinary-tract-infections-in-pregnant-individuals
  • FDA/DailyMed
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