Is Cefuroxime Safe in Pregnancy

Status

caution Last reviewed: 2026-05-16 · Confidence: moderate

Reason

Pregnancy Category B; no adequate human studies. Use only if clearly needed and reviewed by your prescriber.

Drug Information

Brand Name
Ceftin, Zinacef
Generic Name
cefuroxime
Drug Class
cephalosporin antibiotic
FDA Category
B
Rx Status
prescription

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit.

Effects

Pregnancy
Official labeling says use during pregnancy only if clearly needed. No pregnancy dose is listed in labeling.
Mother
May treat infection during pregnancy. Side effects can still occur, and the drug passes into breast milk.
Baby
Available data have not shown a clear link to major birth defects or miscarriage, but data are limited. Cefuroxime can cross the placenta late in pregnancy.

Trimester Notes

1st Trimester
No clear signal of major birth defects in available data, but human data are limited.
2nd Trimester
No clear signal of major birth defects in available data, but human data are limited.
3rd Trimester
Cefuroxime can cross the placenta late in pregnancy. Use only if needed and reviewed by your prescriber.

Conditions & Warnings

  • Consult OB/GYN or prescriber
  • Prescription drug: do not stop or continue without provider review
  • Limited human pregnancy data
  • May be used when benefits outweigh risks

Alternatives

  • Other cephalosporins such as cephalexin may be considered by your prescriber
  • Non-drug options depend on the infection and are not a substitute for treatment

References

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