Cetirizine

Status

caution Last reviewed: 2026-05-16 · Confidence: moderate

Reason

Pregnancy data are reassuring, but official guidance still says use only when needed and with provider review.

Drug Information

Brand Name
Zyrtec
Generic Name
cetirizine
Drug Class
Second-generation antihistamine
FDA Category
B
Rx Status
OTC

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit.

Effects

Pregnancy
No clear increase in miscarriage, preterm birth, or low birth weight has been shown in limited data.
Mother
May cause drowsiness in some people.
Baby
Available official sources do not show an increased risk of birth defects, but data are limited.

Trimester Notes

1st Trimester
Limited data are reassuring, but first-trimester use should be reviewed with your provider.
2nd Trimester
No specific second-trimester warning found in official guidance; use if needed with provider review.
3rd Trimester
No special trimester warning found in official guidance, but use only if needed and review with your provider.

Conditions & Warnings

  • Consult OB/GYN or prescriber
  • OTC drug: pregnancy dosing limits may apply
  • Do not start, stop, or change dose without provider advice

Alternatives

  • Loratadine
  • Corticosteroid nasal spray for allergies if recommended by your provider

References

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