Cyclizine

Status

caution Last reviewed: 2026-05-16 · Confidence: low

Reason

Pregnancy data are limited. Official guidance supports use only when benefits outweigh risks.

Drug Information

Brand Name
Valoid
Generic Name
cyclizine
Drug Class
first-generation antihistamine antiemetic
FDA Category
N/A
Rx Status
OTC

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit.

Effects

Pregnancy
May be used for nausea and vomiting in pregnancy when advised by a clinician.
Mother
May cause drowsiness, dry mouth, and blurred vision.
Baby
Limited human data. Use only if needed.

Trimester Notes

1st Trimester
Limited data. Use only if your clinician thinks the benefit is greater than the risk.
2nd Trimester
May be considered if needed for nausea and vomiting, with clinician guidance.
3rd Trimester
Use only with clinician advice. Watch for sedation and anticholinergic side effects.

Conditions & Warnings

  • Consult OB/GYN or prescriber
  • OTC: pregnancy dosing limits may apply

Alternatives

  • Doxylamine-pyridoxine
  • Pyridoxine (vitamin B6)
  • Ginger
  • Metoclopramide if prescribed

References

  • NHS
    https://www.nhs.uk/medicines/cyclizine/
  • FDA
  • ACOG
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