Is Dilaudid Safe in Pregnancy

Reason

Prolonged use in pregnancy can cause neonatal opioid withdrawal and fetal harm. Use only if provider says benefits outweigh risks.

Drug Information

Brand Name

Dilaudid

Generic Name

hydromorphone

Drug Class

opioid analgesic

FDA Category

N/A (PLLR narrative label)

Rx Status

prescription

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit.

Effects

Pregnancy

May cause fetal harm. Prolonged use may lead to withdrawal in the newborn.

Mother

Can cause sedation, respiratory depression, overdose, and dependence.

Baby

Can cause neonatal opioid withdrawal syndrome, breathing problems, and possible dependence after birth.

Trimester Notes

1st Trimester

Limited human data. Use only if clearly needed and prescribed.

2nd Trimester

Prolonged use still carries risk of fetal dependence and newborn withdrawal.

3rd Trimester

Use near delivery can cause newborn breathing problems and withdrawal. Not recommended during or right before labor unless specifically directed.

Risk-Benefit Note

If pain control is needed, your prescriber should weigh maternal benefit against fetal and newborn risks. Do not stop suddenly without medical advice.

Conditions & Warnings

• Consult OB/GYN or prescriber
• Opioid use disorder
• Chronic pain
• Respiratory disease
• Breastfeeding

Alternatives

• Acetaminophen if your OB/prescriber says it is appropriate
• Non-drug pain measures such as rest, heat or ice if approved by your clinician
• Other treatments your OB/prescriber may recommend based on the cause of pain

References

• FDA label: Dilaudid Injection
  https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/019034s035lbl.pdf
• FDA label: Dilaudid Oral Solution/Tablets
  https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/019891s029,019892s037lbl.pdf
• FDA label: Dilaudid Injection
  https://www.accessdata.fda.gov/drugsatfda_docs/nda/2024/217812Orig1s000OtherR.pdf