Is Flu Shot Safe in Pregnancy

Status

caution Last reviewed: 2026-05-16 · Confidence: high

Reason

CDC and ACOG recommend flu vaccination in pregnancy with inactivated or recombinant products; avoid live nasal spray vaccine.

Drug Information

Brand Name
Flu shot
Generic Name
influenza vaccine (inactivated or recombinant)
Drug Class
Vaccine
FDA Category
N/A (PLLR narrative label)
Rx Status
prescription

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit.

Effects

Pregnancy
CDC and ACOG say it can be given in any trimester; live attenuated nasal spray should not be used in pregnancy.
Mother
Can lower risk of flu and flu-related complications during pregnancy; mild side effects can occur.
Baby
May pass antibodies to the baby and help protect after birth until the baby can be vaccinated.

Trimester Notes

1st Trimester
Can be given in the first trimester; CDC reports no increased risk of miscarriage or birth defects with flu vaccination.
2nd Trimester
Can be given in the second trimester; CDC and ACOG recommend vaccination during pregnancy.
3rd Trimester
Can be given in the third trimester; CDC and ACOG recommend vaccination during pregnancy.

Risk-Benefit Note

Flu infection can be more serious during pregnancy. CDC and ACOG say the flu shot is recommended because benefits outweigh known risks when the correct vaccine type is used.

Conditions & Warnings

  • Consult OB/GYN or prescriber
  • Use only inactivated or recombinant influenza vaccine during pregnancy
  • Do not use live attenuated nasal spray flu vaccine in pregnancy

Alternatives

  • None during flu season; ask your provider which inactivated or recombinant flu vaccine is available.
  • If not vaccinated during pregnancy, vaccinate after delivery if advised.

References

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