Is Flucloxacillin Safe in Pregnancy

Status

caution Last reviewed: 2026-05-16 · Confidence: low

Reason

Limited pregnancy data, but penicillins are generally used in pregnancy when needed. Consult your prescriber.

Drug Information

Brand Name
Floxapen
Generic Name
flucloxacillin
Drug Class
penicillin antibiotic
FDA Category
N/A (PLLR narrative label)
Rx Status
prescription

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit.

Effects

Pregnancy
No official pregnancy dose adjustment is given. Use should be based on need and provider review.
Mother
May cause allergic reactions, diarrhea, or liver problems.
Baby
No specific fetal harm is listed in official U.S. labeling; limited data. Use only if needed.

Trimester Notes

1st Trimester
No trimester-specific warning found in official U.S. sources for flucloxacillin.
2nd Trimester
No trimester-specific warning found in official U.S. sources for flucloxacillin.
3rd Trimester
No trimester-specific warning found in official U.S. sources for flucloxacillin.

Conditions & Warnings

  • Consult OB/GYN or prescriber
  • Prescription drug: do not stop or continue without provider advice
  • Penicillin allergy
  • Liver disease or prior jaundice with penicillins

Alternatives

  • Amoxicillin
  • Cephalexin
  • Cefazolin

References

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