Is Hydrocortisone Cream Safe During Pregnancy

Status

caution Last reviewed: 2026-05-16 · Confidence: moderate

Reason

Most topical hydrocortisone can be used in pregnancy, but use the smallest amount for the shortest time.

Drug Information

Brand Name
Hydrocortisone Cream
Generic Name
hydrocortisone
Drug Class
topical corticosteroid
FDA Category
N/A (PLLR narrative label)
Rx Status
OTC

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit.

Effects

Pregnancy
Use on broken skin, large areas, or for long periods may increase absorption. Higher-potency steroid use has more concern.
Mother
Can help treat itchy or inflamed skin. Too much use can cause skin thinning or more absorption.
Baby
Little of the medicine is expected to reach the baby when used on skin as directed. Large amounts or long use may raise concern.

Trimester Notes

1st Trimester
Most guidance allows use, but keep use small and short. Ask a pharmacist or doctor if unsure.
2nd Trimester
Most guidance allows use, but use the smallest amount needed for the shortest time.
3rd Trimester
Use only if needed and for a short time. Large or prolonged use should be reviewed by a clinician.

Conditions & Warnings

  • Consult OB/GYN or prescriber
  • OTC pregnancy dosing limits may apply
  • Use the lowest potency needed
  • Avoid large areas, broken skin, or long-term use unless told by a clinician

Alternatives

  • Emollients and fragrance-free moisturizers
  • Cool compresses
  • Ask your OB/GYN or pharmacist about pregnancy-appropriate skin treatments

References

  • NHS
    https://www.nhs.uk/medicines/hydrocortisone-for-skin/
  • NHS
    https://www.nhs.uk/medicines/hydrocortisone-for-piles-and-itchy-bottom/pregnancy-breastfeeding-and-fertility-while-using-hydrocortisone-for-piles-and-itchy-bottom/
  • ACOG
    https://www.acog.org/womens-health/faqs/skin-conditions-during-pregnancy
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