Is Hydroxyzine Safe During Pregnancy

Status

avoid Last reviewed: 2026-05-16 · Confidence: moderate

Reason

FDA label says hydroxyzine is contraindicated in early pregnancy; human pregnancy data are limited.

Drug Information

Brand Name
Vistaril, Atarax
Generic Name
hydroxyzine
Drug Class
first-generation antihistamine; anxiolytic
FDA Category
C
Rx Status
prescription

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit.

Effects

Pregnancy
Official labeling says avoid in early pregnancy. Use only if your prescriber decides benefits outweigh risks.
Mother
May cause drowsiness, dry mouth, and other sedating effects. Provider review is needed before use.
Baby
Limited human data. Reported newborn withdrawal-like symptoms near delivery, including jitteriness, jerking, feeding problems, and one seizure.

Trimester Notes

1st Trimester
FDA labeling says hydroxyzine is contraindicated in early pregnancy.
2nd Trimester
Limited human data do not show a clear increase in birth defects, but official labeling still urges caution and provider review.
3rd Trimester
Use near delivery may cause temporary newborn symptoms. Tell the delivery team if you used hydroxyzine late in pregnancy.

Risk-Benefit Note

If hydroxyzine is being used for anxiety, itching, or allergy symptoms, your prescriber should weigh symptom control against pregnancy risks before continuing or changing treatment.

Conditions & Warnings

  • Consult OB/GYN or prescriber
  • Prescription drug: do not start, stop, or continue without provider review
  • Pregnancy data are limited
  • Official label warns against early pregnancy use

Alternatives

  • Diphenhydramine only if your OB/prescriber approves
  • Chlorpheniramine only if your OB/prescriber approves
  • Non-drug options or a different treatment chosen by your prescriber

References

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