Ibuprofen Safe in Pregnancy

Status

avoid Last reviewed: 2026-05-16 · Confidence: high

Reason

Avoid after 20 weeks unless a clinician specifically says to use it; serious fetal kidney and amniotic fluid risks.

Drug Information

Brand Name
Advil, Motrin
Generic Name
ibuprofen
Drug Class
Nonsteroidal anti-inflammatory drug (NSAID)
FDA Category
C
Rx Status
OTC

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit.

Effects

Pregnancy
FDA advises avoiding NSAIDs at 20 weeks or later unless specifically directed by a health professional. If needed, use the lowest dose for the shortest time.
Mother
May raise risk of complications later in pregnancy. Use only if a clinician says the benefit outweighs the risk.
Baby
May cause fetal kidney problems, low amniotic fluid, and at about 30 weeks can affect the baby’s heart circulation. Late use can also cause ductus arteriosus problems.

Trimester Notes

1st Trimester
Use only if your clinician says it is needed. Limited data suggest possible risks, so ask your provider first.
2nd Trimester
Avoid after 20 weeks unless specifically directed. Risk of fetal kidney problems and low amniotic fluid increases.
3rd Trimester
Avoid. NSAIDs can cause fetal heart circulation problems and other complications late in pregnancy.

Conditions & Warnings

  • Consult OB/GYN or prescriber
  • Pregnancy dosing limits may apply
  • Do not use at 20 weeks or later unless specifically directed by a health professional

Alternatives

  • Acetaminophen may be considered if your clinician says it is appropriate
  • Non-drug options such as rest, fluids, ice, or heat if approved by your clinician

References

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