Is Lexapro Safe During Pregnancy

Status

caution Last reviewed: 2026-05-16 · Confidence: moderate

Reason

Official labels warn of late-pregnancy newborn effects and possible PPHN. Benefits may outweigh risks for some patients.

Drug Information

Brand Name
Lexapro
Generic Name
escitalopram
Drug Class
Selective serotonin reuptake inhibitor (SSRI) antidepressant
FDA Category
N/A (PLLR narrative label)
Rx Status
prescription

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit.

Effects

Pregnancy
Use in pregnancy needs individual review. Untreated depression also carries pregnancy risks. Late pregnancy use needs extra monitoring.
Mother
May help treat depression or anxiety. Stopping suddenly can cause relapse or withdrawal symptoms; postpartum bleeding risk may be increased near delivery.
Baby
Late pregnancy exposure may cause poor adaptation after birth, such as breathing trouble, feeding problems, low tone, or temperature instability. Possible PPHN has been reported.

Trimester Notes

1st Trimester
Available data do not suggest an increased risk of birth defects above background risk, but evidence is not perfect.
2nd Trimester
May be continued if benefits outweigh risks; provider review is important.
3rd Trimester
Later pregnancy use may increase the chance of newborn adaptation symptoms and possible persistent pulmonary hypertension.

Risk-Benefit Note

For antidepressants, untreated depression in pregnancy can also harm mother and baby. Your prescriber should weigh relapse risk against medicine risks before any change.

Conditions & Warnings

  • Consult OB/GYN or prescriber
  • Do not stop or continue without provider review
  • Depression
  • Anxiety
  • Late pregnancy monitoring may be needed

Alternatives

  • Psychotherapy
  • Other SSRIs may be considered by your prescriber
  • Non-drug support such as sleep, exercise, and counseling

References

Black Box Warning: Antidepressants may increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults; monitor closely.
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