Is Lidocaine Safe During Pregnancy

Status

caution Last reviewed: 2026-05-16 · Confidence: high

Reason

Pregnancy data are reassuring, but use only when needed and dose must be set by your provider.

Drug Information

Brand Name
Xylocaine
Generic Name
lidocaine
Drug Class
Local anesthetic (amide)
FDA Category
B
Rx Status
prescription

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit. Official labeling for lidocaine injection lists a maximum of 4.5 mg/kg (300 mg) plain or 7 mg/kg (500 mg) with epinephrine.

Effects

Pregnancy
Official labeling reports no identified drug-related risk in human data, but placental transfer occurs and dose matters.
Mother
May cause local numbness, and high doses can cause toxicity or allergic-type reactions.
Baby
Crosses the placenta; high doses or accidental injection may cause fetal heart or nervous system effects.

Trimester Notes

1st Trimester
Use only if clearly needed, especially during organ development.
2nd Trimester
May be used when benefits outweigh risks; lowest effective dose is preferred.
3rd Trimester
May be used if needed; provider should avoid high doses and monitor closely.

Risk-Benefit Note

For needed procedures, treating pain or infection may be better than delaying care. Your prescriber should decide if lidocaine is appropriate for your situation.

Conditions & Warnings

  • Consult OB/GYN or prescriber
  • Dose and route must be reviewed by a provider
  • Use with caution if you have liver disease or heart rhythm problems
  • If dental or minor procedure use is needed, provider should use the lowest effective dose
  • Do not stop or start prescription treatment without prescriber guidance

Alternatives

  • Non-drug measures when appropriate
  • Provider-selected local anesthetic with the lowest effective dose
  • Acetaminophen for pain if your OB/GYN says it is appropriate

References

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