Is Meclizine Safe in Pregnancy

Status

caution Last reviewed: 2026-05-16 · Confidence: moderate

Reason

Limited pregnancy data are reassuring, but use only if clearly needed and reviewed by your prescriber.

Drug Information

Brand Name
Antivert
Generic Name
meclizine
Drug Class
first-generation antihistamine; antiemetic; vestibular suppressant
FDA Category
B
Rx Status
prescription

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit.

Effects

Pregnancy
Use only when needed after provider review. Do not assume it is needed for all nausea or dizziness.
Mother
May cause drowsiness, dry mouth, and dizziness. Can add to sedation from other medicines.
Baby
Human data do not show a clear increase in major birth defects. Animal studies found cleft palate at high doses.

Trimester Notes

1st Trimester
Human data have not shown a clear increase in major birth defects, but data are limited. Use only if needed.
2nd Trimester
May be used if your prescriber thinks the benefit is greater than the risk.
3rd Trimester
Use only if needed and approved by your prescriber. Watch for sedation and dizziness.

Conditions & Warnings

  • Consult OB/GYN or prescriber
  • Prescription medicine; do not stop or continue without provider guidance
  • May cause drowsiness
  • Avoid alcohol and other sedating drugs unless your prescriber says it is okay

Alternatives

  • Non-drug measures for nausea or dizziness as advised by your OB/GYN
  • Doxylamine-pyridoxine if your OB/GYN recommends it for nausea and vomiting of pregnancy
  • Fluids, small frequent meals, and rest if appropriate

References

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