Is Motrin Safe During Pregnancy

Status

avoid Last reviewed: 2026-05-16 · Confidence: high

Reason

FDA warns to avoid NSAIDs at 20 weeks or later; last 3 months of pregnancy also should be avoided unless a doctor directs use.

Drug Information

Brand Name
Motrin
Generic Name
ibuprofen
Drug Class
nonsteroidal anti-inflammatory drug (NSAID)
FDA Category
C
Rx Status
OTC

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit.

Effects

Pregnancy
Can cause oligohydramnios after 20 weeks; avoid in the last 3 months unless specifically directed by a doctor.
Mother
May reduce pain and fever, but pregnancy use needs clinician review because of fetal risks.
Baby
May cause low amniotic fluid and rare fetal kidney problems after 20 weeks; later pregnancy use may also affect the baby’s heart and delivery.

Trimester Notes

1st Trimester
Use only if your prescriber says the benefit is greater than the risk. Data are limited and official labels advise asking a health professional.
2nd Trimester
Use only with clinician advice. FDA warns against NSAID use at 20 weeks or later unless specifically advised; lowest dose and shortest time if needed.
3rd Trimester
Avoid. FDA and OTC labeling warn against use in the last 3 months of pregnancy unless a doctor specifically directs it.

Conditions & Warnings

  • Consult OB/GYN or prescriber
  • OTC pregnancy dosing limits may apply
  • Do not use at 20 weeks or later unless specifically advised by a health professional
  • Avoid use in the last 3 months of pregnancy unless directed by a doctor

Alternatives

  • Acetaminophen may be an option if your OB/GYN says it is appropriate.
  • Non-medicine options for pain relief may help, such as rest, hydration, ice, or heat if approved by your clinician.

References

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