Is Pepcid Safe During Pregnancy

Status

caution Last reviewed: 2026-05-16 · Confidence: moderate

Reason

Pregnancy data are limited but do not show increased birth defect risk; use only if needed and review with your provider.

Drug Information

Brand Name
Pepcid
Generic Name
famotidine
Drug Class
H2 receptor antagonist (acid reducer)
FDA Category
B
Rx Status
OTC

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit. Follow the OTC label unless your clinician gives different directions.

Effects

Pregnancy
No official pregnancy dose is set. If symptoms need treatment, use the lowest effective OTC dose per label and ask your provider.
Mother
May help heartburn/acid reflux. Can cause headache, dizziness, or constipation.
Baby
Available data do not show an increased chance of birth defects. Limited data on other pregnancy outcomes.

Trimester Notes

1st Trimester
Available data do not show an increased chance of birth defects with first-trimester use, but data are limited.
2nd Trimester
No specific trimester warning is listed for famotidine in the official references used here.
3rd Trimester
No specific trimester warning is listed for famotidine in the official references used here.

Conditions & Warnings

  • Consult OB/GYN or prescriber
  • OTC pregnancy dosing limits may apply

Alternatives

  • Lifestyle changes for reflux, such as smaller meals and avoiding trigger foods
  • Antacids approved by your clinician for pregnancy use

References

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