Is Pepto Safe During Pregnancy

Status

avoid Last reviewed: 2026-05-16 · Confidence: high

Reason

Pregnancy use is not recommended; may affect the baby, especially with regular use after 30 weeks.

Drug Information

Brand Name
Pepto-Bismol
Generic Name
bismuth subsalicylate
Drug Class
antidiarrheal/antacid (salicylate-containing)
FDA Category
N/A (PLLR narrative label)
Rx Status
OTC

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit.

Effects

Pregnancy
Official guidance says do not take if pregnant. Risk concern is higher with regular use after 30 weeks.
Mother
May cause black tongue or black stools; aspirin allergy, gout, bleeding, diabetes, or PKU may matter.
Baby
May expose the baby to salicylate; regular use after 30 weeks may be harmful.

Trimester Notes

1st Trimester
Do not take in pregnancy unless a clinician specifically advises it.
2nd Trimester
Do not take in pregnancy unless a clinician specifically advises it.
3rd Trimester
Do not take, especially regular use after 30 weeks.

Conditions & Warnings

  • Consult OB/GYN or prescriber
  • Pregnancy
  • Breastfeeding
  • Aspirin allergy
  • Blood clotting disorder
  • Gout
  • Diabetes
  • Phenylketonuria (chewable tablets may contain aspartame)

Alternatives

  • Oral rehydration fluids for diarrhea
  • Diet changes for indigestion/heartburn
  • Ask your OB/GYN or pharmacist for pregnancy-safe medicine options
  • Vitamin B6/doxylamine for nausea if recommended by your clinician

References

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