Is Phenergan Safe in Pregnancy

Status

caution Last reviewed: 2026-05-16 · Confidence: moderate

Reason

FDA category C. Limited pregnancy data. Use only if benefit outweighs risk; consult your OB/GYN or prescriber.

Drug Information

Brand Name
Phenergan
Generic Name
promethazine
Drug Class
phenothiazine antihistamine; antiemetic
FDA Category
C
Rx Status
prescription

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit.

Effects

Pregnancy
Should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.
Mother
Can cause drowsiness, dizziness, dry mouth, and other sedating effects.
Baby
Limited data do not show an increased birth-defect risk above background, but newborn drowsiness or low platelet effect near delivery is possible.

Trimester Notes

1st Trimester
Limited human data. Use only if clearly needed and after provider review.
2nd Trimester
Limited human data. Use only if clearly needed and after provider review.
3rd Trimester
Use caution near delivery. Labeling notes use within 2 weeks of delivery may inhibit platelet aggregation in the newborn.

Risk-Benefit Note

Promethazine may be used in pregnancy when preferred options do not control symptoms, but the dose and need should be reviewed by a clinician.

Conditions & Warnings

  • Consult OB/GYN or prescriber
  • Prescription drug: review before starting, stopping, or continuing
  • May affect pregnancy testing or glucose tolerance testing

Alternatives

  • doxylamine-pyridoxine (Diclegis)
  • pyridoxine (vitamin B6)
  • provider-directed non-drug measures for nausea

References

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