Is Prednisone Safe During Pregnancy

Status

caution Last reviewed: 2026-05-16 · Confidence: high

Reason

Official sources note possible fetal harm and small first-trimester cleft risk; use only if benefits outweigh risks.

Drug Information

Brand Name
Prednisone
Generic Name
prednisone
Drug Class
systemic corticosteroid
FDA Category
N/A (PLLR narrative label)
Rx Status
prescription

Safe Amount

Dosage must be determined by your provider based on individual risk/benefit.

Effects

Pregnancy
Long-term use has been linked to preterm birth and low birth weight, but illness being treated may also cause these risks.
Mother
May raise blood sugar, blood pressure, and risk of infection; do not stop suddenly without provider guidance.
Baby
Small possible risk of oral clefts in the first trimester; long-term use may affect growth and newborn adrenal function.

Trimester Notes

1st Trimester
Small possible increase in oral clefts has been reported; newer reviews suggest any increase is very small.
2nd Trimester
Main concern is ongoing maternal dose and the condition being treated; provider monitoring is important.
3rd Trimester
Long-term use may be linked with preterm birth, low birth weight, and possible newborn adrenal suppression.

Risk-Benefit Note

Prednisone is often continued in pregnancy when needed to treat asthma, autoimmune disease, or other serious illness. The benefits may outweigh the risks.

Conditions & Warnings

  • Consult OB/GYN or prescriber
  • Pregnancy dosing must be determined by your provider based on individual risk/benefit
  • Do not stop suddenly without medical advice
  • If used long-term, newborn monitoring may be needed

Alternatives

  • No direct substitute fits every condition; ask your OB/GYN or prescriber about the lowest effective dose or other pregnancy-compatible options for your condition

References

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